The sales package includes a total of three pairs of silicone ear tips (the Medium ones are pre-fitted on the earphones), but there’s no Micro-USB cable for charging. Even at this price, skipping a charging cable is unfortunate; not everyone necessarily has one at home, especially those buying entry-level affordable products..The Redmi SonicBass Wireless Earphones use Bluetooth 5, with support for only the SBC Bluetooth codec. AAC support would have been nice here, but I won’t go as far as to say that it’s a shortcoming, given the price. Interestingly, there is multi-point connectivity, letting you pair the Redmi SonicBass earphones with two source devices simultaneously. This worked well, and I was able to quickly switch between my smartphone and laptop while using the earphones.Battery life is decent enough for the price, with the Redmi SonicBass Wireless Earphones running for around 10 hours per charge, and taking around two hours to charge fully using a wall adapter. The headset is IPX4-rated for water resistance, and should be able to handle sweat and light splashes of water.The Redmi SonicBass Wireless Earphones magnetically latch to each other, but this doesn’t control the power Xiaomi’s strategy means that the company now has two key brands under its core banner – Mi and Redmi – with all of its products classified into either of the two families. The Redmi brand is positioned as the more reasonably priced of the two, while Mi-branded products are a bit more premium. Indeed the company’s most affordable smartphones and audio products have the Redmi badge on them. This includes a recently launched audio product, the Redmi SonicBass Wireless Earphones, priced at Rs. 1,299.Following the launch of the Redmi Earbuds S and other competitively priced products, the Redmi SonicBass Wireless Earphones promise a more traditional style of earphones at a popular price point, along with the bass-focused sonic signature that many buyers seem to prefer. How do these affordable wireless earphones sound? Find out in our review.- Advertisement – There isn’t much to talk about when it comes to design; this is just about the most utilitarian pair of wireless earphones you can buy Punchy bass on the Redmi SonicBass Wireless EarphonesThe product name itself is a big giveaway in terms of what to expect when it comes to sound, and indeed there are no surprises here. The sonic signature is tuned to give low-end frequencies a bump, and I could perceive this bass bias with pretty much everything I listened to using the Redmi SonicBass earphones. However, it’s worth pointing out that there isn’t much else to the sound apart from this bump in the bass; this is otherwise an entirely ordinary-sounding pair of earphones.That isn’t a bad thing though, since the Redmi SonicBass does have all the basics in place. You get comfortable sound that isn’t fatiguing or odd in any way. This makes for an adequate listening experience that lines up nicely with the price and functionality of the earphones.The Redmi SonicBass is a budget wireless headset and only supports the SBC Bluetooth codec, so the quality of the source audio had very little impact on the listening experience. Whether listening to high-resolution Tidal Masters streams or YouTube Music’s occasionally low-bitrate tracks, there wasn’t too much of a difference in how the earphones sounded.Listening to the beautiful Golden Brown by The Stranglers across streaming services confirmed this, but it didn’t actually take away too much from the quality of the sound given the price of the Redmi SonicBass earphones. The lows were expectedly more pronounced, with the drums in the track reverberating noticeably strongly. The mid-range and highs sounded a bit dull in comparison to the lows, but weren’t overpowered to an unreasonable extent; the earphones produced a safe sonic signature that was never offensive or muddy.Barry White’s Never Never Gonna Give You Up sounded similarly interesting, with hints of directionality throughout. Some of the gentler elements in the track did feel spacious, but the bass bias did tend to restrict the soundstage. There wasn’t much by way of good imaging or detail, with the tuning of the Redmi SonicBass earphones focused on keeping things clean and comfortable, rather than trying too hard to offer more and falling short.Although not exceptional for voice calls, the Redmi SonicBass Wireless earphones are adequate for the purpose. Environmental noise cancellation is present and permanently active when on calls, but didn’t seem to make too much of a difference in improving voice quality for people on the other end of the call, while they sounded a bit boomy and low to me. The earphones were good enough for the occasional call, and could be used reasonably well at distances of up to 12 feet from the source device.The Redmi SonicBass Wireless Earphones offer decent sound for the price, making this a good budget pick VerdictOften, the biggest mistake that manufacturers of affordable audio products make is trying to offer too much, and getting the basics wrong in the process. Xiaomi hasn’t done that with the Redmi SonicBass; this is an entirely functional pair of wireless earphones that gets the basics right. The fit and design are workable, the strong bass will appeal to a lot of listeners, and multi-point connectivity makes the headset a whole lot more useful. There are only a couple of small drawbacks on the whole.Although priced at Rs. 1,299 officially, the Redmi SonicBass Wireless Earphones are available for Rs. 999 at the time of writing this review, making this quite easily the best pair of wireless earphones you can buy for less than Rs. 1,000, and still a pretty good deal even for Rs. 300 more.Price: Rs. 1,299ProsMagnetically attaching earpiecesIPX4 water resistanceMulti-point connectivityStrong bass, comfortable sonic signatureConsAnnoying cables, lots of cable noiseNo charging cable in the boxRatings (out of 5)Design/ comfort: 3.5Audio quality: 3Battery life: 3.5Value for money: 4.5Overall: 3.5 There really isn’t much to the Redmi SonicBass Wireless Earphones when it comes to design and styling; this is just about as straightforward and basic as it gets. The neckband is flexible at the back, with larger, solid ends which hold the Bluetooth hardware, battery, and audio circuitry. The left end has a barely-noticeable Redmi logo etched on, while the right has the power and volume buttons, Micro-USB port for charging, and indicator light.You can buy the Redmi SonicBass earphones in one of two colours, black or blue-black. While the black was a bit more muted and discreet, the dual-tone blue-black option might appeal to buyers looking for something colourful. Although the earpieces are comfortable to wear, the cables running between them and the neckband did tend to get in the way and brush against my face, which generated a fair amount of cable noise.The main button plays and pauses music, or answers and ends calls with a single press. You can invoke the default voice assistant on your smartphone with a double-press. A long-press powers the earphones on or off, and holding for a few more seconds when turning the Redmi SonicBass on puts it into pairing mode. The earpieces attach to each other magnetically, but this doesn’t control the power as on some other headsets; it’s just to keep the wires from tangling when not in use.- Advertisement – Simple, functional design on the Redmi SonicBass Wireless Earphones- Advertisement – How to find the best deals during online sales? We discussed this on Orbital, our weekly technology podcast, which you can subscribe to via Apple Podcasts, Google Podcasts, or RSS, download the episode, or just hit the play button below. – Advertisement –
Qatar Airways Group, chief executive, Akbar Al Baker, said: “We are delighted to continue rebuilding our network, resuming routes and adding new destinations. “We have made it our priority to not only restart most of our existing destinations as soon as possible but also to launch new routes. “With more than 700 weekly flights currently to just over 100 destinations, and plans to increase our network to more than 125 destinations by the end of the IATA winter season, our passengers will enjoy more options to travel when they want across the globe, safely and reliably.” Qatar Airways resume flights and increase services to several destinations in the coming weeks, the carrier has announced. The Middle Eastern airline will fly to Algiers twice a week from November 13th, with Chicago to follow, with nine flights a week starting from November 15th. – Advertisement – In between, on November 14th, a twice weekly service to Miami will resume, while there will also be 14 flights a week to New York. Next month, Kiev will welcome three flights a week from December 18th, two flights a week will depart for Phuket from December 4th, with three flights a week for Seychelles and Warsaw from December 15th and December 16th, respectively. The national carrier of the Qatar will also launch two new destinations in December with one weekly flight to Luanda, Angola starting from December 14th and four weekly flights to San Francisco from December 15th.- Advertisement – OlderABTA issues new plea for government support- Advertisement – – Advertisement –
Green Bay Packers wide receiver Marquez Valdes-Scantling roams the globe on an amazing 78-yard touchdown, with a little help from the ref! It was a difficult day for the Green Bay Packers in a potential trap game. Their defensive frailties were once again exploited by James Robinson. The undrafted free agent may not have scored a touchdown, but he did pick up 100 yards on 23 carries. The Packers run defense continues to be gashed and if they have designs on winning the Super Bowl then they will need to address their ability to defend the run inside.In poor weather conditions, Aaron Rodgers’ connection with Marquez Valdes-Scantling was a shining light. The two hooked up on four passes for 149 yards and a touchdown. It has been a committee of players serving as the number two option in Green Bay, but it was a breakout day for Valdes-Scantling. He could have just cemented himself as Davante Adams’ running mate. Sonny CohenUp Next – Jaguars v Steelers (Sunday, 6pm), Packers @ Colts (Sunday, 9.25pm)Houston Texans 7-10 Cleveland Browns – Advertisement – – Advertisement – A look back at the action and talking points from Week 10 of the NFL season. Ronald Jones takes the pigskin for a massive 98 yards to the endzone on one carry, with the Buccaneers backed up down at their two-yard line after a Panthers punt. Third down is becoming a hindrance for this young and exciting Panthers defense, which was blown away in the end by an angry Bucs team. Phil Snow’s unit entered the game worst on third down in the league before allowing the Bucs to convert 10 of 16 opportunities on third down. The Bucs put up points at the end of a drive in which they had converted on third down every time.There was also a reminder to Bruce Arians and Byron Leftwich to persist with the run game as Ronald Jones went off for a career-best 192 yards, including a franchise-long 98-yard touchdown burst. The Bucs seemed to abandon things on the ground pretty early on in last week’s defeat to the Saints, instead looking to use Jones and Leonard Fournette in screen plays. The Bucs have the catalogue of weapons that mean they shouldn’t have to use either prominently in the passing game. Cameron HogwoodUp Next – Buccaneers v Rams (Tuesday, 1.15am), Panthers v Lions (Sunday, 6pm)Cincinnati Bengals 10-36 Pittsburgh SteelersThe Steelers moved to 9-0 for the first time in franchise history as they dominated the Bengals. Despite not being around the training facility for the most recent week due to COVID-19 restrictions, Ben Roethlisberger showed no rust at all.If anything the veteran quarterback looked all the better for the week of rest. He threw for a season-high 333 yards and four touchdowns. Big Ben shared the love among all of his receiving options on Sunday, all three of JuJu Smith Schuster, Diontae Johnson and Chase Claypool catching a touchdown pass.It really was business as usual for Roethlisberger as he secured his 24th victory against the Bengals, who he has beaten more times than any other team he has faced in his 16-year career. Sonny CohenUp Next – Bengals @ Washington (Sunday, 6pm), Steelers @ Jaguars (Sunday, 6pm)Jacksonville Jaguars 20-24 Green Bay Packers Tua Tagovailoa moved to 3-0 as Miami Dolphins starter, Daniel Jones got his first win against a non-Washington team since his debut, Kyler Murray connected with DeAndre Hopkins on a stunning Hail Mary and the Seattle Seahawks’ defensive woes continued; here’s a look at what we learned in Week 10. Buffalo Bills 30-32 Arizona Cardinals 0:40 There was a delay in Cleveland as a nasty storm hit, delaying the Browns’ game against the Texans. 0:32 San Francisco 49ers quarterback Nick Mullens throws an 8-yard pass to tight end Jordan Reed, which he grabbed centimetres from the ground! There was a delay in Cleveland as a nasty storm hit, delaying the Browns’ game against the Texans. Before Sunday, Cleveland’s season had followed a very readable path. Score more than 30 and they win, score less than 10 and they lose. It all added up to a 5-3 record in an AFC North that is proving to be quite the battle.On Sunday, in windy conditions, they managed 10 points and a pair of running backs in the returning Nick Chubb and Kareem Hunt both rushing for more than 100 yards. It was the perfect recipe for victory and their fewest points in a winning game since 2012 (per NFL research).Houston’s season already looks like a write-off. Head coach rumours and front office reshuffles mean it looks like being a messy season and offseason, without much draft capital to boot. For Cleveland, having found a new way to win this season, they’ll now go in search of back-to-back wins for the first time since Week Five. Paul PrendervilleUp Next – Texans v Patriots (Sunday, 6pm), Browns v Eagles (Sunday, 6pm)Denver Broncos 12-37 Las Vegas RaidersDrew Lock might be playing for his job. The Broncos quarterback’s teething problems were evident once more as he finished just 23 of 47 for 257 yards, one touchdown and four interceptions in a bruising defeat to the Raiders. Inconsistencies were again weaved between moments of promise, Lock struggling to sustain drives, missing open receivers and throwing awkwardly off his back foot when the pressure came – which was more often than not. You can partly blame a rather mediocre offensive line, but Lock must has to shoulder some of what’s going on.We also learned that a change of scenery can do one a world of good. Devontae Booker rushed for 81 yards and two touchdowns on the night – more than he had in his entire 2019 season with the Broncos, whose own failure to establish a ground game is meanwhile a familiar concern this season. Cameron HogwoodUp Next – Broncos v Dolphins (Sunday, 9.05pm), Raiders v Chiefs (Monday, 1.20am)Sky Sports NFL will be your dedicated channel for NFL coverage through the season – featuring a host of NFL Network programming, a new weekly preview show as well as at least five games a week and NFL Redzone, you won’t miss a moment. Watch as Kyler Murray’s Hail Mary pass finds DeAndre Hopkins in the endzone as the Cardinals win it at the death. Of course, we simply have to start with that stunning finish in Arizona.There is nothing quite like a Hail Mary touchdown, let alone a game-winner with two seconds left. Even then, there was something extra special about Kyler Murray’s to DeAndre Hopkins – the way Murray avoided pressure, broke a tackle, the way he then threw back across his body when rolling out left, the arm strength, and then, of course, Hopkins’ catch.Talk about clutch. The strength too. In triple coverage (though Buffalo surely should have had more defenders manning the endzone), Hopkins went up highest and then clung on for dear life, muscling out the other defenders as he came down with the football to clinch a quite incredible victory. David CurrieUp Next – Bills BYE WEEK, Cardinals @ Seahawks (Friday, 1.20am)Seattle Seahawks 16-23 Los Angeles RamsWhere to start? The trajectory of this Seahawks team is worrying, and yet again on Sunday we learned that Russell Wilson will need to be near-flawless for this side to challenge in the playoffs.Seattle are missing Chris Carson in the backfield, injuries on the offensive line are exposing Wilson to a familiar world of hurt (six sacks, 12 QB hits) and there is little reason to trust this defense getting off the field. You only have to attack somebody not named Bobby Wagner or Jamal Adams in order to have a chance of putting up points on this unit.Wilson stepping up and out of the pocket before gifting Darious Williams an interception was perhaps a concerning sign of perhaps him forcing things amid a turbulent period. Cameron HogwoodUp Next – Seahawks v Cardinals (Friday, 1.20am), Rams @ Buccaneers (Tuesday, 1.15am)Washington Football Teams 27-30 Detroit LionsAn opportunity missed for Washington, who looked well set to haul themselves into the race for the NFC East title, but Matt Prater’s 59-yard field goal clinched a much-needed first home win of the season.Prater’s kick was good but it wasn’t even the longest of the week after Jason Myers landed from 61 on a stellar weekend for the league’s kickers, but Matt Stafford’s ability to move the Lions within range so quickly is worth highlighting, again!The last word goes to Alex Smith, the quarterback who was fighting for his life after a serious leg injury almost two years ago. Just playing is something of a miracle but that he threw for 390 yards and completed 38 of his 55 passes in helping Washington fight back from 24-3 down in the third quarter deserves special praise. Paul PrendervilleUp Next – Washington v Bengals (Sunday, 6pm), Lions @ Panthers (Sunday, 6pm)Baltimore Ravens 17-23 New England Patriots Wide Receiver Jakobi Myers throws a perfect 24 yard touchdown pass to Rex Burkhead in the New England Patriots victory over the Baltimore Ravens. What is that saying? Something along the lines of ‘don’t write off the Patriots?’Don’t get it twisted, New England, at 4-5, still have a lot of work to do even after this win – their second-straight for the first time this season – but they are certainly not giving up this division to the upstarts of Buffalo and Miami just yet!Cam Newton threw his first touchdown pass since Week Three. He missed the Week Four defeat to Kansas City after getting Covid and did not look himself in New England’s next couple of outings, but there are promising signs that he and the Patriots are just starting to click on offense.As for the Lamar Jackson and the Ravens. It was by no means an ugly loss, especially given the desperate conditions in which the game was played – torrential rain and heavy wind – but this defeat does nothing to help the narrative that they can’t win the big games David CurrieUp Next – Ravens v Titans (Sunday, 6pm), Patriots @ Texans (Sunday, 6pm)Los Angeles Chargers 21-29 Miami DolphinsThe Miami Dolphins are making a serious run for the playoffs with their fifth straight win. Tua Tagovailoa continues to impress since taking over from Ryan Fitzpatrick following the Miami bye week as he threw for two more touchdowns in his 3-0 start to life in the NFL.Miami’s defense has proven to be the cornerstone of the team this season and Sunday was no different. They managed to restrict rookie quarterback Justin Herbert, punctuated by a pick by Xavien Howard – his fifth of the season.The Dolphins special teams kickstarted the game early on, as linebacker Andrew Van Ginkel blocked a punt that was recovered on the one-yard line. Salvon Ahmed capitalised with an easy touchdown run and the Dolphins never looked back. Sonny CohenUp Next – Chargers v Jets (Sunday, 9.05pm), Dolphins @ Broncos (Sunday, 9.05pm)San Francisco 49ers 13-27 New Orleans Saints San Francisco 49ers quarterback Nick Mullens throws an 8-yard pass to tight end Jordan Reed, which he grabbed centimetres from the ground! Another frustrating loss for San Francisco, whose hopes of repeating their run to the Super Bowl from last year are fading faster with every passing week and passing defeat – that’s three on the trot now for the 49ers (4-6).They started this one well, racing out to a 10-0 lead in the first quarter, whole the defense kept up their end of the bargain – limiting the Saints to just 17 points through the first three quarters, keeping them in the contest – but the offense and special teams badly let the team downThe 49ers muffed two punt returns to gift New Orleans brilliant field position, while QB Nick Mullens was also picked off twice.Speaking of quarterbacks, concerning for the Saints is the fact that a banged-up Drew Brees didn’t return for the second half – one to monitor. In his absence, Jameis Winston came in and didn’t let anybody down, completing 6 of 10 for 63 yards. David CurrieUp Next – 49ers BYE WEEK, Saints v Falcons (Sunday, 6pm)Philadelphia Eagles 17-27 New York GiantsAround the NFL‘s Dan Hanzus last week described the NFC East as an ‘all-time dumpster fire’ and that may be so but someone has to emerge triumphant from the division, so why not the Giants?While the Eagles have a loaded, if injured, roster they are falling well below the sum of their parts and have just three wins for the season – a record that’s placed questions marks over quarterback Carson Wentz.The Giants joined them on three wins and are now just a half game behind Philadelphia and in stark contrast look much more that the sum of their parts. It suggests a first-year coach in Joe Judge getting things right and a team playing for him. In this season, in this NFC East that might be enough to get them top spot and an unlikely play-off spot. Paul PrendervilleUp Next – Eagles @ Browns (Sunday, 6pm), Giants BYE WEEKTampa Bay Buccaneers 46-23 Carolina Panthers 0:40 Wide Receiver Jakobi Myers throws a perfect 24 yard touchdown pass to Rex Burkhead in the New England Patriots victory over the Baltimore Ravens. 1:58 Ronald Jones takes the pigskin for a massive 98 yards to the endzone on one carry, with the Buccaneers backed up down at their two-yard line after a Panthers punt. A look back at the action and talking points from Week 10 of the NFL season. – Advertisement – 4:00 1:28 Watch as Kyler Murray’s Hail Mary pass finds DeAndre Hopkins in the endzone as the Cardinals win it at the death. 0:33 Green Bay Packers wide receiver Marquez Valdes-Scantling roams the globe on an amazing 78-yard touchdown, with a little help from the ref! – Advertisement –
Home Depot is set to report third-quarter earnings on Tuesday before the market opens as the retailer rides a wave of increased buying across the home improvement sector driven by the pandemic.With people spending more time at home and some leaving cities during the pandemic for spacious homes in the suburbs, Home Depot and its rival Lowe‘s have seen a surge in sales. It began in the spring, when both were deemed essential businesses as other retailers shuttered, and it continued into the summer as people traveled less and tackled more projects at home. Analysts will be watching to see whether the company was able to sustain the momentum heading into the fall.Here’s what Wall Street was expecting for the fiscal third quarter, based on a survey of analysts by Refinitiv:EPS: $3.06 expectedRevenue: $32.04 billion expected- Advertisement – – Advertisement – A customer wears a protective mask while unloading purchases off a cart outside a Home Depot Inc. store in Reston, Virginia, on Thursday, May 21, 2020.Andew Harrer | Bloomberg | Getty Images Home Depot announced Monday that it agreed to acquire the remaining shares of HD Supply, a former unit and one of North America’s largest industrial products distributors, in a deal valued at $8 billion. Home Depot spun off HD Supply in 2007 to a group of private equity firms that included Carlyle Group, Bain Capital and Clayton, Dubilier & Rice.The deal could help Home Depot cement its leading edge in the professional contractors business. Lowe’s has been trying to capture a greater share of that side of the business, but Home Depot remains dominant. Along with do-it-yourself projects, the professionals market has boomed during the pandemic, too.Lowe’s will report fiscal third-quarter earnings before the market open on Wednesday.- Advertisement – – Advertisement – As of Monday’s close, shares of Home Depot are up 28% since Jan. 1. The stock, which has a market value of nearly $301 billion, touched an all-time high on Aug. 27 of $292.95.—CNBC’s Melissa Repko contributed to this report.This story is developing. Please check back for updates.
The company said it would meet with the FDA as soon as possible to discuss how to satisfy the agency’s requirements so the trial can proceed. See also: The delay of the clinical trial is the second major setback for VaxGen this year. In May the company announced that the delivery of its vaccine would be delayed at least a year beyond the original target date of November 2006. The delay prompted the US Department of Health and Human Services (HHS) to issue VaxGen a “cure notice,” which says HHS may cancel the vaccine contract if the company doesn’t solve the problem promptly, the firm said in a Nov 4 news release. In late September HHS held a workshop to hear the concerns of biotechnology firms, academic institutions, and the medical community regarding the BioShield program. Also, legislation has been introduced in Congress to help companies that are developing BioShield products more easily clear financial and regulatory hurdles. May 11 CIDRAP News story “New anthrax vaccine for US stockpile delayed”http://www.cidrap.umn.edu/cidrap/content/bt/anthrax/news/may1106anthrax.html In a Nov 3 press release, the Brisbane, Calif., company said the Food and Drug Administration (FDA) ordered the delay because it was concerned about a possible decline in the vaccine’s potency during the immunization phase of the phase 2 clinical trial, which could cloud the study results. “The notification is not related to any adverse event or preclinical finding related to the vaccine,” VaxGen said in its press release. In 2004, HHS awarded VaxGen an $877.5 million contract, the first awarded under Project BioShield, to develop an anthrax vaccine for the civilian stockpile. The goal of Project BioShield is to develop medical defenses against chemical, biological, and radiological weapons. The contract was to produce 75 million doses, enough to vaccinate 25 million people. The VaxGen anthrax vaccine is intended to replace Anthrax Vaccine Adsorbed (AVA), an older, whole-microbe anthrax vaccine used primarily by the US military. The older vaccine, controversial because of reported side effects, requires six doses over 18 months, whereas the VaxGen anthrax vaccine is expected to require three doses. The active ingredient in the VaxGen vaccine is a recombinant form of an anthrax protein called protective antigen (rPA). Nov 6, 2006 (CIDRAP News) VaxGen Inc., which is developing a new anthrax vaccine for the US civilian stockpile, announced last week it was postponing the latest clinical trial because of potential problems with the vaccine’s shelf life. In March, the Washington Post reported that a human trial of VaxGen’s vaccine revealed problems with its potency, and the company said the vaccine lost strength within a few months. At the time, VaxGen said rPA reacted with an aluminum hydroxide adjuvant (immune-boosting substance), but the company believed it had found a solution after experimenting with different formulations. Also in May, the Government Accountability Office issued a report that said the government’s contract with VaxGen was too rigid and might discourage other biotechnology companies from pursuing Project BioShield contracts. Developing new vaccines is expensive, difficult, and often fraught with testing and production delays.
Apr 19 WHO summary of H5N1 treatment recommendations A study of the feasibility of an intravenous formulation “Today we can satisfy significant additional orders from governments and corporations, and unless demand picks up, Roche will be tailoring its production schedule accordingly,” said William M. Burns, chief executive officer of Roche’s pharma division, in a press release. Plans to cut productionDespite the continuing pandemic threat, demand for Tamiflu seems to be dropping off, Roche executives said at a press briefing today. Eugene Tierney, global head of virology and transplantation for Roche, told reporters the company has so far this year received orders for only 215 million doses, most of which have already been produced. However, he lauded governments that are encouraging businesses to prepare their own pandemic plans. He said corporate Tamifu programs for employees can help ensure that critical goods and services are delivered during a pandemic. Roche said it has received Tamiflu orders from more than 250 corporations, accounting for about 5 million doses. The company said it would maintain stocks of the ingredients it uses to make Tamiflu throughout its supply chain and would maintain close contact with its manufacturing partners so that it could respond quickly to surges in demand. Jan van Koeveringe, head of Roche’s pharma global technical operations, told reporters it would take 4 months to restore production to its current output level. Current and future research activities and collaborations, he said, also include: Apr 26 Roche press release Citing mathematical models that appeared in the medical literature in 2005 and 2006, Reddy said countries could decrease the clinical attack rate of a circulating pandemic virus by boosting their stockpiles to levels that would allow not just treatment of sick patients but also preventive use (postexposure prophylaxis) for their household and other contacts. Government antiviral stockpiles that cover only 20% to 25% of a population may not be enough to mitigate the impact of an influenza pandemic, Reddy said. Reddy said Roche is concerned that many government Tamiflu stockpile programs lack important details such as priority lists of groups to receive the drug, detailed logistical plans for distribution, and clarifications on treatment versus prevention. In response to stockpile demands and the desire of some businesses to supply their employees with Tamiflu, Roche geared up its manufacturing capacity to more than 400 million doses per year. The company, at the request of the US Department of Health and Human Services (HHS), upgraded its US supply chain to utilize US sources for all phases of Tamiflu production and can now produce 80 million doses a year in the United States. “We’ve taken capacity constraints out of the equation now,” said David Reddy, leader of Roche’s pandemic taskforce, at today’s press conference. “The question now is how much do governments want to be prepared for wave one of a pandemic?” Apr 26, 2007 (CIDRAP News) – The Swiss pharmaceutical company Roche announced today it is scaling back production of oseltamivir (Tamiflu) because of waning demand, and simultaneously questioned whether countries stockpiling the drug are buying enough to protect their citizens in the event of an influenza pandemic. According to the modeling studies, Reddy said, stockpiling enough Tamiflu for 57% of a country’s population would allow it to provide enough treatment and postexposure prophylaxis, including family contacts, to lower its clinical attack rate during a pandemic to 22%. Stockpiling enough for 102% of the population would enable a country to expand prophylaxis to other contacts and reduce the clinical attack rate to 13%, he said. Postexposure prophylaxis case studies See also: Preclinical virology studies to characterize how different H5N1 strains respond to Tamiflu Reddy said the same research group, known as the Southeast Asia Influenza Clinical Research Network, also has plans to study long-term prophylaxis for healthcare workers. A 6-week course has already been studied and approved, he said, but the researchers will explore whether 20 weeks of preventive treatment for healthcare workers is safe and effective. Roche questions stockpiling goalsTierney said that among the more than 80 countries stockpiling Tamiflu, coverage plans vary widely. For example, Greece and Brazil plan to buy enough to treat about 5% of their populations, whereas Switzerland, Kuwait, Luxemborg, Australia, and France aim to have enough to treat more than 40% of their populations. The US stockpile plan would cover 25% of the population. Research directionsIn other comments, the company said several studies are under way to clarify how to make optimal use of Tamiflu. For example researchers from Southeast Asia and the United States will soon test whether doubling the standard dosage of Tamiflu will improve patients’ chances of overcoming either the often-deadly H5N1 virus or severe seasonal flu. Monitoring of H5N1 virus resistance to Tamiflu Two events would prompt Roche to restore production to full capacity, van Koevering said: if inventories of key Tamiflu ingredients drop below target levels, or if the WHO raises the pandemic alert level from 3 to 4 (signaling increased human-to-human transmission). Safety profile studies for Tamiflu use in children younger than 1 year. The World Health Organization (WHO) recommends the antiviral drug as the first-line treatment for patients who have H5N1 avian influenza and has advised countries to stockpile it. In its most recent H5N1 treatment update, released last week, the WHO reaffirmed its Tamiflu recommendations. An avian flu registry to collect clinical data on the virus and use of Tamiflu Mar 29 CIDRAP News article “International network to study high-dose Tamiflu”
Jun 21, 2007 (CIDRAP News) – Agriculture officials in the Czech Republic today confirmed the country’s first H5N1 avian influenza outbreak in poultry, while Vietnamese officials announced the death of another human H5N1 patient, the country’s second in 2 weeks.Josef Vitasek, a Czech veterinary official, said the virus infected nearly 2,000 turkeys in a 6,000-bird flock near the village of Tisova in the eastern part of the country, according to a Deutsche Presse-Agentur (DPA) report. He said the remaining birds would be culled today and that authorities have imposed 3- and 10-km security zones around the farm.Czech News Agency reported that none of the turkeys from the farm have been distributed to retail outlets, according to a Reuters report today.The turkey outbreak marks the second confirmed appearance of H5N1 in the Czech Republic. In the spring of 2006, 12 wild swans tested positive for the disease, according to reports from the World Organization for Animal Health (OIE). The dead swans were tested as part of a national surveillance program, according to the report. The country has never had a confirmed human H5N1 case.Europe’s last H5N1 outbreak occurred in February at a British turkey farm. Agriculture officials said that outbreak was probably linked to an earlier outbreak in Hungarian turkeys.Also today, health officials in Vietnam said a 28-year-old woman died of an H5N1 infection, according to the Associated Press (AP). In view of previous news reports, the woman appears to be one of the two recent H5N1 case-patients announced by Vietnam on Jun 12. The woman, from Ha Nam province, about 37 miles south of Hanoi, was previously reported to be in critical condition at the Hospital for Tropical Diseases in Hanoi.Nguyen Hong Ha, deputy hospital director, told the AP that she died today after 13 days in the hospital. The woman had had contact with sick poultry, the AP report said.With the woman’s death, Vietnam’s apparent H5N1 human toll is 98 cases with 44 deaths. The World Health Organization has not yet confirmed 5 cases, including 2 fatal ones, reported by Vietnam in recent weeks, so the WHO count for Vietnam remains at 93 cases with 42 deaths.The 20-year-old man who was announced on Jun 16 as Vietnam’s most recent H5N1 fatality was from Ha Tay province, one of 18 Vietnamese provinces affected by a recent spate of poultry outbreaks, mostly in duck flocks, the AP report said.In other news, agriculture officials in Ghana said the H5N1 virus has been confirmed in poultry in the Volta region town of Aflao, bringing the number of affected regions to three, the African news service Joy News reported 2 days ago. The discovery led to the culling of 1,100 birds in the area around Aflao, Ben Aniwa, the region’s veterinary services director, told Joy News.Ghana reported its first H5N1 outbreak in early May, making it the ninth African country to be hit by the disease. No human cases have been confirmed.See also:Apr 27, 2006, OIE report on infected swans in Czech RepublicJun 13 CIDRAP News story “Vietnam reports two H5N1 cases”
Apr 23, 2009 (CIDRAP News) – Five more cases of an unusual swine influenza virus infection have surfaced, officials from the US Centers for Disease Control and Prevention (CDC) announced today, bringing the total to seven and raising more concerns about human-to-human transmission.The new cases include two clusters, two 16-year-old boys in San Antonio, Tex., who attended the same school and a father and daughter from San Diego County. Anne Schuchat, MD, interim deputy director for the CDC’s science and public health program, told reporters today at a teleconference that the clusters are consistent with human-to-human spread.She also said that the World Health Organization has not raised its six-phase pandemic alert level above phase 3 (no or very limited human-to-human transmission).The fifth new case occurred in a patient from Imperial County, which borders San Diego County. Both counties are home to the first two swine flu patients that the CDC announced on Apr 21.News of the five new swine flu cases came on the same day Canadian officials warned its public health, medical, and quarantine workers to look for illnesses among Canadians returning from Mexico. Mexico has reported several cases of severe respiratory illness and has asked Canada to assist in finding the source of the illnesses, some of which have been fatal, according to a report today from the Canadian Press (CP).Schuchat said no swine flu cases have been confirmed in Mexico or Canada, but that CDC officials are discussing the situation with Mexican health officials and representatives from the Pan American Health Organization (PAHO).Novel strain, relatively mild symptomsConcerning the seven American cases, Schuchat said, “The good news is that all of the patients have recovered, and one was hospitalized. This is not looking like a very severe influenza.”Patients experience fever, cough, and sore throat symptoms similar to typical influenza, but some of the patients who had swine influenza also experienced more diarrhea and vomiting than is typical of seasonal flu.The CDC said genetic sequencing of samples from the first two patients, California children who lived in adjacent counties, show that the swine flu virus contains segments from four different viruses: some North American swine, some North American avian, one human influenza, and two Eurasian swine.”This virus hasn’t been recognized in the USA or elsewhere,” Schuchat said.CDC scientists have determined that the novel swine flu virus is resistant to the older antivirals rimantadine and amantadine but is susceptible to oseltamivir and zanamivir.Schuchat said the CDC expects to see more swine flu cases and that it would provide regular updates on its Web site.”This is not time for major concern around the country, but we want you to know what’s going on,” she said. Most of the public health response will focus on the California and Texas areas where cases have been identified, but the CDC is urging health departments in other states to heighten their awareness of respiratory illnesses, particularly in those who have had contact with pigs or traveled to the San Diego or San Antonio areas.Schuchat said the CDC doesn’t know yet if the H1N1 component of this season’s influenza vaccine provides any protection against the swine flu virus, but she said studies are under way to determine if there is any cross-protection.Expert reactionMichael T. Osterholm, PhD, MPH, director of the University of Minnesota Center for Infectious Disease Research and Policy, publisher of CIDRAP News, said the findings, though concerning, don’t mean that a pandemic is imminent.However, he said health officials shouldn’t take comfort in the fact that the illnesses so far have been mild. “The first wave of the 1918 pandemic was mild, too,” Osterholm pointed out.Walter Dowdle, PhD, who worked in the CDC’s virology unit during the 1976 swine flu outbreak, told CIDRAP News that it’s interesting but not greatly alarming that the 2009 swine flu strain contains such an unusual mix of gene segments.”It’s a real mutt,” said Dowdle, who now works with the Task Force for Child Survival and Development, based in Atlanta. “When you have an evolving RNA mechanism, it’s hard to be surprised by anything.”The H1N1 component of the seasonal flu vaccine might provide some degree of protection, he said. And if the swine flu virus persists, federal officials could consider adding an additional H1N1 strain to next year’s vaccine.Marie Gramer, DVM, PhD, a University of Minnesota veterinarian who has studied swine flu, said her preliminary examination shows that the outbreak strain doesn’t appear to closely match anything currently circulating in pigs. However, Gramer added that she has only looked at a small number of viruses and only at the hemagglutinin gene.Risk message implicationsPeter Sandman, PhD, a risk communication consultant based in Princeton, N.J., also listened in on today’s CDC teleconference. While he credited the CDC with getting a clear, calm, and concise scientific message out about the swine flu cases, he said they missed a teachable moment to promote pandemic preparedness.”Everyone needs to learn how to say ‘This could be bad, and it’s a good reason to take precautions and prepare’ and ‘This could fizzle out,'” Sandman said. “They need to simultaneously say both statements.”He added that “good risk communicators need to know how to be both scary and tentative.”Federal health officials are probably treading cautiously around the word “pandemic,” because some accused them of fearmongering when they raised concerns about the H5N1 virus 2 years ago and also because of overreaction during the 1976 swine flu epidemic that led to vaccination missteps.When talking to the public about pandemic risks, federal officials could take some cues from hurricane forecasters, Sandman said, “and speculate responsibly.”Canadian officials probe Mexico illnessesCanada’s Public Health Authority (PHAC) said today in a situation update that Mexican authorities have asked its assistance in determining the cause of two clusters of severe respiratory illnesses that have occurred this month.A cluster in Mexico City involved 120 cases and 13 deaths; the other occurred in San Luis Potosi, where 14 cases and 4 deaths were reported. Three deaths were reported from other locations: One from Oaxaca in southern Mexico and two from Baja California Norte, near the US border.The PHAC report said the disease outbreak struck some healthcare workers and that most patients were previously healthy young adults between the ages of 25 and 44. Symptoms included fever, headache, ocular pain, shortness of breath, and fatigue that rapidly progressed to severe respiratory distress in about 5 days.Mexican officials detected some influenza A/H1N1 and influenza B viruses, but have apparently ruled out H5N1 virus involvement. The PHAC said it received 51 clinical samples from Mexico for testing at its National Microbiology Lab.Mexico told the PHAC that it had a late influenza season with an increasing number of influenza-like illnesses since the middle of March. The country also had a higher proportion of influenza B viruses than previous seasons.See also:Apr 21 CIDRAP News story “Human swine flu cases with unique train raise concern”Apr 22 CIDRAP News story “Swine flu cases recall 1976 episode”CDC swine flu investigation pageCDC swine flu information
Apr 25, 2009 (CIDRAP News) – Health officials from Kansas and New York today announced more confirmed and probable swine influenza cases, as an emergency panel of the World Health Organization (WHO) met but stopped short of raising the global pandemic alert level.The WHO said in a statement today that the emergency panel, after reviewing data on the US and Mexican outbreaks, identified several gaps in the information about clinical features, epidemiology, and virology. “The Committee nevertheless agreed that the current situation constitutes a public health emergency of international concern,” the WHO said.Many public health officials had speculated that the group might advise raising the pandemic alert level from phase 3 to 4, but it has yet to take that step.Based on the determination of the committee, Margaret Chan, the WHO’s director-general, advised all countries to intensify their surveillance for unusual influenza-like illnesses and severe pneumonia.At a media teleconference this morning, Chan said the WHO would like to know, for example, how many of Mexico City’s 800 severe illness cases were caused by the new swine flu virus and how many were caused by other pathogens. “We may need a few more days to gather other evidence,” she said.”Nonetheless, this is a serious situation that must be watched very closely,” she said.The US Centers for Disease Control and Prevention (CDC) tonight updated its number of confirmed swine flu cases, adding one more patient from California and the two announced by Kansas today, raising the total from 8 to 11.No new totals were available about the number of Mexican swine flu cases or fatalities. Several media reports said Mexican government officials cancelled a number of cultural events and ordered crowds to stay away from two popular soccer matches that were scheduled for today.Cases in Kansas and New YorkAt a press conference late this afternoon, the Kansas Department of Health and Environment (KDHE) said that the two patients who tested positive for the swine flu A/H1N1 strain circulating in the United States and Mexico are both adults who live in the same household, one of whom had recently traveled to Mexico. Neither was hospitalized. One of the patients is still sick and is being treated, and the other is recovering.Kansas officials said they first received a report of unusual flulike illness yesterday afternoon. After preliminary tests conducted overnight were positive this morning, KDHE officials flew the samples on Gov Kathleen Sebelius’ plane to the CDC in Atlanta, which confirmed the swine flu findings by midafternoon.Shortly before Kansas announced its findings, the New York City Department of Health and Mental Hygiene announced that 8 of 9 samples obtained from students sickened at a private high school were positive for an untyped influenza A strain.Thomas R. Frieden, MD, MPH, the department’s commissioner, told reporters that those findings suggest human swine flu. He said the samples are on their way to the CDC for confirmation and that results should be available tomorrow.Several media outlets have reported that the school is Saint Francis Preparatory School, located in Queens. The school’s Web site said on Apr 23 about 75 students reported to the medical office with symptoms including headache, upset stomach, and dizziness.The New York City health department has received calls about students from Manhattan, not associated with Saint Francis, who were sick and undergoing medical evaluation after traveling to Mexico for spring break, Frieden said. The department is also investigating a respiratory illness outbreak at a daycare center in the Bronx and is sending specimens for testing.Frieden said about 200 students had been absent and that health officials have spoken with about 100 of them. Illnesses had a short incubation period (1 to 3 days), symptoms have been mild, none of the students were hospitalized, and most of the teens report feeling better.If the CDC confirms the findings tomorrow, Frieden said he’ll recommend that the school not reopen on Monday. “Schools can become amplifiers,” he said.So far, the New York City department of health, based on its syndromic surveillance, hasn’t detected an increase in respiratory illness patterns in the city. “But we’re monitoring that every 12 hours,” he said.CDC: ‘Time to prepare’Earlier in the afternoon, before Kansas and New York announced their findings, the CDC briefed reporters on the status of the swine flu investigation. At that point, it had no new cases to report, just the seven that the agency has confirmed at that point.However, Anne Schuchat, MD, director of the CDC’s National Center for Immunization and Respiratory Diseases, said to expect more case announcements as state surveillance progresses. She pointed out that the CDC yesterday issued outbreak notices for travelers and technical bulletins on the swine flu virus for laboratory workers, infection control officials, and healthcare workers.”Many of these actions are really taken with an abundance of caution—you’ll see a lot going on,” she saidSchuchat said the CDC isn’t resting easy about the mild cases seen so far in the United States. “That may change. This is the time to prepare, to think ahead, and be ready for some uncertainty,” she said.Though the WHO hasn’t elevated its pandemic alert level, the CDC continues to prepare for more serious outbreak scenarios, she said. “It’s easy to focus on phases, but it’s important to know we are preparing. We’re not trying to focus on the classification,” Schuchat said.Mild cases may mean littleMichael T. Osterholm, PhD, MPH, director of the University of Minnesota Center for Infectious Disease Research and Policy, publisher of CIDRAP News, also urged public health officials to view the data about the severity difference between the US and Mexican cases with caution.Though subsequent passages of the virus through populations could lead to a milder disease, it’s difficult to base conclusions about the mild severity of US cases on such a small number of patients, he said.Health officials don’t know yet how many mild cases of swine flu occurred in Mexican patients, and without that information, it’s difficult to draw firm conclusions about the true rate of severe cases, he said.”Milder cases, on one hand, are good, but that may mean little,” Osterholm said, adding that, during the first wave of the 1918 influenza pandemic in the spring, many cases were mild, but by late July and early August, the virus caused widespread, severe illness.Preparing emotionally and physically for a possible pandemicPeter Sandman, PhD, a risk communication consultant based in Princeton, N.J., told CIDRAP News that a key task for the public health community right now extends beyond tangible items such as stockpiles of food, drugs, and supplies. “Preparing is also envisioning how bad a pandemic could be,” he said, adding that some degree of anxiety and feeling a knot in the stomach is a crucial part of an adjustment reaction.Evidence has shown that those who can envision what could happen down the road do better at coping with a crisis situation, Sandman said. “The time to do that is now.”See also:Apr 25 WHO statementApr 25 KDHE press releaseApr 25 NYCDHMH press releaseSaint Francis Preparatory School Web siteApr 24 CIDRAP News story “Labs confirm same swine flu in deadly Mexican outbreaks”Apr 23 CIDRAP News story “More US swine flu cases, Mexico illnesses raise pandemic questions”CDC swine flu investigation pageCDC swine flu informationPeter Sandman article “Adjustment reactions: the teachable moment in crisis communication” (Spanish version also at this link)
The new tourist season at the Duboka camping resort started on April 1, 2018, and judging by the arrivals in the first month, a great season awaits them.Duboka Camp Resort, located in the Papuk Nature Park, is an investment worth 2,8 million kuna including VAT, and was financed through the PARCS project with a grant from the Global Environment Facility, whose beneficiary is the Ministry of Environmental Protection and Energy in cooperation with the United Nations Development Program (UNDP) in Croatia.Kamo rest area covers 8.000m2 and has a total of 32 accommodation units with a capacity of up to 96 guests. Of that, 11 units are equipped with electrical and plumbing connections for camper vehicles. “We are extremely pleased to have returnee guests who have spread the good word about the camp and this time came in a real caravan. These are guests from Germany who travel to Albania every year and look for small camps in natural oases. The guests stayed in the camp for two days, exploring the beauties of the first Croatian UNESCO Geopark ” stand out from PP Papuk.The peculiarities of the Duboka Camping Resort have been recognized by the Croatian Camping Association, and it has been included in the list of 38 best small campsites in Croatia as part of the OK Mini Camps quality standard certification project, a project to encourage camp quality and education supported by the Ministry of Tourism. Thanks to its position, the camp is an ideal starting point for visiting the Papuk Nature Park and offers the opportunity to enjoy the many gastronomic specialties for which this part of Slavonia is widely known.The first tourist season at the Duboka camping resort attracted over 200 visitors who spent 320 nights. The structure of visitors is dominated by foreign guests from Western European countries. It is interesting to note that these are guests who are just looking for campsites located in areas with preserved nature, and the Duboka campsite meets all their requirements, which shows the need for the same content on the continent.The environment of the camp offers numerous recreational opportunities such as hiking, sport climbing, cycling or jogging, and the camp is well connected to the main hiking and biking trails in the park.Related news:CAMP RESORT – ZLATNI LUG OPENED IN POŽEGACAMPSITIES RECEIVE 67% OF NIGHTS GROWTH