Roche cuts Tamiflu production as demand cools

first_img Apr 19 WHO summary of H5N1 treatment recommendations A study of the feasibility of an intravenous formulation “Today we can satisfy significant additional orders from governments and corporations, and unless demand picks up, Roche will be tailoring its production schedule accordingly,” said William M. Burns, chief executive officer of Roche’s pharma division, in a press release. Plans to cut productionDespite the continuing pandemic threat, demand for Tamiflu seems to be dropping off, Roche executives said at a press briefing today. Eugene Tierney, global head of virology and transplantation for Roche, told reporters the company has so far this year received orders for only 215 million doses, most of which have already been produced. However, he lauded governments that are encouraging businesses to prepare their own pandemic plans. He said corporate Tamifu programs for employees can help ensure that critical goods and services are delivered during a pandemic. Roche said it has received Tamiflu orders from more than 250 corporations, accounting for about 5 million doses. The company said it would maintain stocks of the ingredients it uses to make Tamiflu throughout its supply chain and would maintain close contact with its manufacturing partners so that it could respond quickly to surges in demand. Jan van Koeveringe, head of Roche’s pharma global technical operations, told reporters it would take 4 months to restore production to its current output level. Current and future research activities and collaborations, he said, also include: Apr 26 Roche press release Citing mathematical models that appeared in the medical literature in 2005 and 2006, Reddy said countries could decrease the clinical attack rate of a circulating pandemic virus by boosting their stockpiles to levels that would allow not just treatment of sick patients but also preventive use (postexposure prophylaxis) for their household and other contacts. Government antiviral stockpiles that cover only 20% to 25% of a population may not be enough to mitigate the impact of an influenza pandemic, Reddy said. Reddy said Roche is concerned that many government Tamiflu stockpile programs lack important details such as priority lists of groups to receive the drug, detailed logistical plans for distribution, and clarifications on treatment versus prevention. In response to stockpile demands and the desire of some businesses to supply their employees with Tamiflu, Roche geared up its manufacturing capacity to more than 400 million doses per year. The company, at the request of the US Department of Health and Human Services (HHS), upgraded its US supply chain to utilize US sources for all phases of Tamiflu production and can now produce 80 million doses a year in the United States. “We’ve taken capacity constraints out of the equation now,” said David Reddy, leader of Roche’s pandemic taskforce, at today’s press conference. “The question now is how much do governments want to be prepared for wave one of a pandemic?” Apr 26, 2007 (CIDRAP News) – The Swiss pharmaceutical company Roche announced today it is scaling back production of oseltamivir (Tamiflu) because of waning demand, and simultaneously questioned whether countries stockpiling the drug are buying enough to protect their citizens in the event of an influenza pandemic. According to the modeling studies, Reddy said, stockpiling enough Tamiflu for 57% of a country’s population would allow it to provide enough treatment and postexposure prophylaxis, including family contacts, to lower its clinical attack rate during a pandemic to 22%. Stockpiling enough for 102% of the population would enable a country to expand prophylaxis to other contacts and reduce the clinical attack rate to 13%, he said. Postexposure prophylaxis case studies See also: Preclinical virology studies to characterize how different H5N1 strains respond to Tamiflu Reddy said the same research group, known as the Southeast Asia Influenza Clinical Research Network, also has plans to study long-term prophylaxis for healthcare workers. A 6-week course has already been studied and approved, he said, but the researchers will explore whether 20 weeks of preventive treatment for healthcare workers is safe and effective. Roche questions stockpiling goalsTierney said that among the more than 80 countries stockpiling Tamiflu, coverage plans vary widely. For example, Greece and Brazil plan to buy enough to treat about 5% of their populations, whereas Switzerland, Kuwait, Luxemborg, Australia, and France aim to have enough to treat more than 40% of their populations. The US stockpile plan would cover 25% of the population. Research directionsIn other comments, the company said several studies are under way to clarify how to make optimal use of Tamiflu. For example researchers from Southeast Asia and the United States will soon test whether doubling the standard dosage of Tamiflu will improve patients’ chances of overcoming either the often-deadly H5N1 virus or severe seasonal flu. Monitoring of H5N1 virus resistance to Tamiflu Two events would prompt Roche to restore production to full capacity, van Koevering said: if inventories of key Tamiflu ingredients drop below target levels, or if the WHO raises the pandemic alert level from 3 to 4 (signaling increased human-to-human transmission). Safety profile studies for Tamiflu use in children younger than 1 year. The World Health Organization (WHO) recommends the antiviral drug as the first-line treatment for patients who have H5N1 avian influenza and has advised countries to stockpile it. In its most recent H5N1 treatment update, released last week, the WHO reaffirmed its Tamiflu recommendations. An avian flu registry to collect clinical data on the virus and use of Tamiflu Mar 29 CIDRAP News article “International network to study high-dose Tamiflu”last_img read more

Governor Wolf Opposes Gutting of Independent Redistricting Commission Bill

first_img SHARE Email Facebook Twitter Governor Wolf Opposes Gutting of Independent Redistricting Commission Bill April 11, 2018center_img Press Release,  Redistricting,  Voting & Elections Harrisburg, PA – Governor Tom Wolf today released the following statement on the House State Government Committee Republican ​majority’s last-minute move to gut and replace House Bill 722, originally to create an independent redistricting commission, with a redistricting process that is more politically driven:“This is partisan politics at its worst and it shows a flippant disregard for thousands of citizens that have spoken in favor of independent redistricting and ending gerrymandering. After the last few months, it should be clear that the solution to our broken redistricting system is not putting more power in the hands of partisan politicians. This is wrong, and it is an affront to our democracy. I urge the full House to reject this partisan political power play and demand a vote on a truly independent redistricting commission.”last_img read more

Magpies focus on European targets

first_img Bafetimbi Gomis was in their sights before Swansea came up with a more financial package which better suited the players, and their interest in Hertha Berlin’s Pierre-Michel Lasogga is ongoing. They are understood too to be monitoring Lyon forward Alexandre Lacazette’s situation, while they are hoping to make progress on Montpellier midfielder Remy Cabella on his return from the World Cup finals. In the meantime, the club are bracing themselves for offers for some of their key players with full-back Debuchy and keeper Tim Krul having been linked with moves away from St James’ Park this summer. But having sold Cabaye for rather less than they had hoped, there is little chance of any potential suitor getting a bargain this time around. Press Association Pardew told the Shields Gazette: “The fees being paid for players such as Luke Shaw and, it seems, Adam Lallana, illustrate an important point that supporters need to understand. “Clubs like Newcastle get accused of not signing English players, but these are prices mid-table teams in the Premier League simply cannot afford, unlike Champions League clubs with their extra revenue. “We recently inquired about an unproven player not in the side at one of our top clubs, and we were asked [for] £14million. He will not be joining. “Yet we can pick up players such as Yohan Cabaye, Mathieu Debuchy and Moussa Sissoko for reasonable fees, all of whom have been starring for France at the World Cup.” Cabaye, Debuchy and Sissoko cost Newcastle a combined total of around £11million, with Cabaye leaving for Paris St Germain in January for around £19million. The Magpies, armed with chief scout Graham Carr’s knowledge of the European market, have been active on that front once again this summer having landed 20-year-old Tenerife striker Ayoze Perez and entered into discussions over a series of potential targets. Ironically, their only other signing to date is Sunderland’s Academy graduate midfielder Jack Colback, who has joined the club as a free agent. However, Pardew’s squad needs significant further strengthening with strikers a priority. Alan Pardew has admitted Newcastle will concentrate on Europe rather than Britain as they look for value for money in the summer transfer market. The Magpies have looked to the continent, and France in particular, in recent years for reinforcements having refused to pay premium rates for home-grown players. Manchester United’s £30million capture of Southampton full-back Luke Shaw and Liverpool’s ongoing £25million pursuit of Adam Lallana are cases in point, while even at a more modest level, Hull paid Tottenham £8million for Jake Livermore and struck a deal which would eventually amount to much the same figure with Norwich for Robert Snodgrass. last_img read more

Ellsworth’s Higgins receives coaching honor

first_imgELLSWORTH — The National High School Coaches Association named Ellsworth’s Brian Higgins as 2017 High School Girls’ Tennis Coach of the Year on Friday.Higgins, who is Maine’s winningest tennis coach with over 600 victories, has led the girls’ team to five state runner-up finishes in his tenure as coach. He also coaches the boys’ team, with which he won a state championship in 1996.“We are extremely pleased to honor Coach Higgins as National Girls’ Tennis Coach of the Year,” NHSCA Executive Director Eric Hess said in a statement. “Coach Higgins’ commitment to excellence for his student-athletes on and off the tennis [court] makes him an excellent choice for this honor.”Higgins is the second coach from Maine to receive the award. Lewiston’s Anita Murphy became the first when she did so in 2011.This is placeholder textThis is placeholder textHiggins will receive a trophy and a spot in the National High School Sports Hall of Fame Museum, which the NHSCA’s Mattie Potter said will be built “in the near future.”last_img read more

Women’s volleyball looks for first win this weekend

first_imgPhoto courtesy of Sports InformationSet on the stars · Junior setter Reni Meyer-Whalley and the women’s volleyball team have three matches to earn their first win of the season.The women’s volleyball team (0-3) will be looking for their first win of the season in the USC Radisson Classic after dropping all three matches in the USC Baden Invitational last weekend. “We need all three,” head coach Mick Haley said. “We need to be 3-3 after this weekend if we can.”Last weekend was a rough start for the Women of Troy. They lost in four sets to Marquette and Santa Clara and then got swept by UC Irvine. Hitting and service errors plagued the team, totaling up 110 errors through three matches. “We started on Monday by saying we want Christmas to be over here,” Haley said. “We’re not in a giving mood anymore.”Practice this week offered a fresh start in  hopes of a renewed level of play this weekend. Haley said practices have been productive. At Wednesday’s practice, everyone was working hard, cheering each other on and dialed in. “We’ve changed a few things, but not too much,” Haley said. “So I think we’re getting close.”While not having starting setters is the main source of their problems on the court, the team’s youth is another component they’re dealing with. “I’ve got my young kids, that are wonderful athletes, having to carry a pretty big load pretty quickly in their lives,” Haley said. “But that’s what they signed up for.”In terms of the setter battle, all four are still in contention for this weekend, but senior Alice Pizzasegola and junior Reni Meyer-Whalley “are in the driver seat” right now. Senior setter Alexa Strange, a two-time national champion and All-American in beach volleyball, hasn’t played organized indoor volleyball since her freshman year at Nebraska in the fall of 2012. “Strange is starting to come on here now, not as a setter but just as a player,” Haley said. “She’s really liking this right now.”Junior setter Nikki Leonard is the other player in contention. Haley praised her raw athleticism and her coachability and emphasized the need to get her more relaxed on the court. “Leonard is showing that she can take instruction right now,” Haley said. “We just need to get her to play without making too many errors.”For Haley, it comes down to the team finding confidence in themselves and each other for everything to start clicking on the court. “All they need is one person that can step up,” Haley said. “And then, we can be a team that was as good as last year’s team.”This season, it looks like the spark plug could be freshman outside hitter Khalia Lanier. She had back-to-back double-digit kills to close out the tournament and was the only USC player to make the Baden Invitational All-Tournament team. “Khalia is good enough to do that, but I just don’t want to put that kind of pressure on her yet,” Haley said. “But we may have to try, because if we get ourselves in a hole here, we’re going to be in trouble.”The team will face a higher level of competition in No. 22 Creighton (1-1), No. 23 Kentucky (2-1) and Northern Iowa (2-1) than they did last weekend in three unranked opponents. The Women of Troy have never lost to any of these teams in the 10 combined times they’ve faced them. For USC to save the start of the 2016 season, they will need to keep their perfect records against these teams. “So I’m pretty optimistic; I’m usually the pessimist,” Haley said. “I’m optimistic that maybe we can turn this around, you know?”The Women of Troy kick of the USC Radisson Classic tonight night at 8 p.m. against No. 23 Kentucky. On Saturday, they face Northern Iowa at 10 a.m. and No. 22 Creighton at 8 p.m.last_img read more

A.J. Pollock’s ‘bad three games’ land him on Dodgers’ bench for Game 4

first_imgSHORT-TIMERSWith Beaty replacing Pollock, Gavin Lux starting at second base as he has against right-handed pitching and Will Smith back at catcher after Russell Martin caught Hyun-Jin Ryu on Sunday, the Dodgers’ starting lineup for Game 4 featured three rookie position players.It is not the first time Roberts has written three rookies onto a postseason lineup card – Corey Seager, Andrew Toles and Julio Urias started Game 4 of the 2016 NLCS against the Chicago Cubs. But it is the first time three rookie position players started a postseason game for the Dodgers since Seager, Joc Pederson and Kiké Hernandez started Game 5 of the 2015 NLDS against the New York Mets.Roberts said he never even gave a thought to the experience level of the trio as he was making out the Game 4 lineup.“I believe in the players. I believe in the talent,” Roberts said. “There’s guys every year across baseball who are young players who make an impact. The service time, I have no hesitation running those guys out there.”Roberts said “the overriding decision is what gives you the best chance to win tonight” and he has no fears that any of the Dodgers’ young players will be overwhelmed by the moment.Related Articles Dodgers’ Max Muncy trying to work his way out of slow start “But it’s something that I haven’t at all lost confidence in A.J. and know that he’ll figure some things out.”Roberts said the NLDS slump reminds him of the funk Pollock was in at the start of the season. Pollock was batting .223 in late April when an elbow injury sidelined him for more than two months.“Yeah, it does. And that’s why I feel confident he and our hitting guys will clean it up,” Roberts said. “But it’s very clear … that they’re spinning him (throwing breaking balls). Going forward, that’s what teams are going to do until he adjusts. That’s just a fact.”Roberts said the slump “came out of nowhere.” Over the final two months of the regular season, Pollock batted .297 with an .887 OPS.“It’s a bad three games,” Roberts said. “I expect considerably better going forward. Getting back to simplifying. I talked to him today. He’s worked through some things mechanically. But he’s fine. His head is good.” How Dodgers pitcher Ross Stripling topped the baseball podcast empire Newsroom GuidelinesNews TipsContact UsReport an Error Fire danger is on Dave Roberts’ mind as Dodgers head to San Francisco center_img WASHINGTON — Taken individually, A.J. Pollock’s at-bats in the first three games of the Dodgers’ National League Division Series were not pretty. Added together, it gets even uglier.Pollock was 0 for 11 in the first three games with nine strikeouts. Not surprisingly, the veteran outfielder was not in the starting lineup for Game 4, replaced by left-handed hitter Matt Beaty against Nationals starter Max Scherzer on Monday night.Pollock faced Scherzer as a pinch-hitter in the fourth inning — and struck out to make it an 0-for-12 series for him.“I think right now he’s struggling with spin,” Dodgers manager Dave Roberts said. “And I think that there’s more chase in there than there has been in the second half of the season, for whatever reason – mechanical, maybe a little bit of pressing. So I think that to give him a blow, get Matt in there, get as many left-handed bats against Scherzer as possible, I think gives us the best chance to win tonight. Cody Bellinger homer gives Dodgers their first walkoff win of season Dodgers hit seven home runs, sweep Colorado Rockies “Fortunately, we have had young players as part of our roster in past years that we felt confident could handle this stage,” he said. “And Matt Beatty, Will Smith, Gavin Lux, are no different. So, we just expect them to do what they can do.”KELLY CALLReliever Joe Kelly failed to retire any of the four batters he faced in Game 3, walking three, throwing a wild pitch and giving up a single. Roberts said there was no physical issue with Kelly, who pitched very little in the final two weeks of the season due to an “overall body situation” that was never explained.“To be honest with you, looking at the scoreboard, I think he was just too fine,” Roberts said, referring to the 8-2 lead Kelly was trying to protect at the time. “I thought he should have gone after (Anthony) Rendon more. He got too fine, kind of led to the walk, led to another walk then the base hit.”Roberts said Kelly was available to pitch in Game 4.last_img read more

New York Reg Hits Ocwen on Backdated Foreclosure Notices

first_img New York’s top banking supervisor once again set his sights on Ocwen Financial Corp. this week, saying the non-bank servicer sent thousands of foreclosure warnings to borrowers months after it was too late to save their homes.In a letter released earlier this week, Benjamin Lawsky, superintendent of financial services for New York, said an investigation of Ocwen’s mortgage servicing practices turned up more than 7,000 letters sent to borrowers that had been backdated and sent only after their payment deadlines had passed.”In many cases, borrowers received a letter denying a mortgage loan modification, and the letter that was dated more than 30 days prior to the date that Ocwen mailed the letter. These borrowers were given 30 days from the date of the denial letter to appeal that denial, but those 30 days had already elapsed by the time they received the backdated letter,” Lawsky said in the letter, which was addressed to executives and board directors at Ocwen.In other cases, Lawsky said, Ocwen’s systems showed borrowers facing foreclosure received notices to cure their default months after the cure date had already passed.In addition, Lawsky claims the company ignored concerns brought up by an employee that its letter dating processes were inaccurate and misrepresented the severity of the problem to his team when questioned about it.”The existence and pervasiveness of these issues raise critical questions about Ocwen’s ability to perform its core function of servicing loans,” Lawsky said.This week’s letter is just the latest regulatory headache for Ocwen, the largest non-bank operating in the mortgage servicing space. The company has seen tighter scrutiny from Lawsky and other federal and state bank regulators in the last year as they turn their attention to independent servicers, who have grown significantly as banks come under heavier regulation.On Wednesday, a group of state bank supervisors—including a representative from Lawsky’s New York office—announced the formation of a new task force to analyze growth and practices at non-bank servicers in the hope of developing workable servicing standards for that segment.In a statement, Ocwen said the backdating issue stems from software errors in correspondence systems. While the company is not certain how many borrowers received backdated letters, it believes it has resolved the issues that have been found so far.”We are continuing to review the rest of the cases,” the company said. “We are working with and fully cooperating with DFS and the Monitor to address their concerns.”A spokesperson representing the company turned down a request for an interview. October 23, 2014 538 Views in Daily Dose, Government, Headlines, News, Servicing New York Reg Hits Ocwen on Backdated Foreclosure Noticescenter_img Benjamin Lawsky Compliance Ocwen Regulation 2014-10-23 Tory Barringer Sharelast_img read more